Friday, November 30, 2012

Q3 Internet Services Launches New Range of Cloud Hosting ...

Q3 Internet Services is one of the specialists in providing internet based products including SSL certificates and web hosting services. Q3 is located in Birmingham and provides services to over 4000 customers.Q3 Internet Services provides affordable services on windows or Linux platform based on cloud infrastructure. Q3 Internet Services also provide EV SSL certificates, SSL certificates and Wildcard SSL certificates. Q3 Internet Services provide excellent services to all its customers with highly trained staffs. Some of the major clients of Q3 Internet Services include National Trust, Interflora, AA and Samsung.

Q3 Internet Services has launched new range of shared web hosting packages for its business customers. This new hosting packages starts from ?2.49 /month. Packages from Q3 Internet Services will be tagged with highest level of web site security and with a 99.99% guaranteed up-time. Q3 also offers fully managed hosting and SSL certificates.

Managing Director at GlobalSign SSL provider and Linux cloud server reseller,?Q3 Internet Services, Raj Sukkersudha said, ?Our shared web hosting plans are a cost-effective solution for getting your website online. Each hosting plan offers a range of features as standard including a Linux operating system, rapid activation, a 99.9% up-time promise and a 14-day money-back guarantee. At Q3?we?pride ourselves in our customer service and?our hosting engineers are highly skilled and trained. We are also firm believers in the Cloud. In fact our entire infrastructure is powered by it. We believe that shared cloud hosting can provide the perfect hosting solution for virtually any business. For companies that are running out of space, or simply want to move to a Cloud-based model, we can re-scale their server, normally within two hours.?

Commenting on recent research study by Q3, Raj Sukkersudha said, ?A poorly thought-out web hosting decision can cause all sorts of problems down the line, as a business becomes more reliant on its online presence for new leads, or to provide support to its customers. If the website doesn?t function well, is plagued with performance issues and/or is difficult to update readily, this will reflect badly on the business and have an impact on the?customer experience,?harming sales. A company?s web presence today is no longer a nice-to-have, it is core to an organization?s brand and as a result companies cannot leave their web hosting choices to chance.?

www.webhostingchat.com?updates its site everyday. Visit us for more news from the web hosting world.

Source: http://www.webhostingchat.com/2012/11/q3-internet-services-launches-new-range-of-cloud-hosting-packages-for-businesses/

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A Skin Cancer Detection and Prevention Chart | PHILANTHROPY ...

Melanoma

A great chart, by Wendy Bryan of I Heart Guts, helping people detect and prevent skin cancer.

(via Laughing Squid)

Categories: Uncategorized | Tags: art, design, health |

Source: http://philanthropyfactory.com/2012/11/29/a-skin-cancer-detection-and-prevention-chart/

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Asia stocks up on hopes for a US budget deal

(AP) ? Signs that U.S. political leaders may be closing in on a budget deal to avoid the so-called "fiscal cliff" boosted Asian stock markets Thursday.

Comments by President Barack Obama and Speaker of the House John Boehner that a deal to avoid a budget crisis could be reached before year's end was enough to boost markets in the face of disappointing U.S. home sales, a critical indicator of whether the economy is improving.

Japan's Nikkei 225 index rose 0.7 percent to 9,377.91. Hong Kong's Hang Seng jumped 1.1 percent to 21,942.92 and South Korea's Kospi added 0.9 percent to 1,930.15. Australia's S&P/ASX 200 gained 0.6 percent to 4,473.70. Benchmarks in Singapore, Taiwan and mainland China also rose.

Obama and the U.S. Congress have until Jan. 1 to agree on how to trim the country's unwieldy deficit. Otherwise, a series of automatic tax increases and sharp spending cuts will take effect that could drag the world's No. 1 economy into recession. Obama said Wednesday he believes a "framework" for an agreement can be reached before Christmas.

"It's really a headline market at the moment. We'll probably continue to see headlines on the fiscal cliff supersede any economic data until it is resolved," said Stan Shamu of IG Markets in Melbourne. "The longer it stretches out, the more risk there is that it will cause further volatility in the markets. But for now, it seems markets are on the right track."

Among Japanese stocks, Nakayama Steel Works shot up 32.5 percent after a Nikkei business daily reported the company will seek restructuring and loan waivers from banks. Kobe Steel gained 4.2 percent. Export-dependent shares also rose, including Yamaha Motor Co., up 4.7 percent; and Honda Motor Co., up 2 percent.

Hong Kong-listed property shares also posted solid gains, including Evergrande Real Estate Group, which jumped 6.1 percent. China Resources Land advanced 3.5 percent.

Concern that the U.S. will go over the fiscal "cliff" has weighed on stocks since the Nov. 6 elections returned a divided government to power, with Obama staying in the White House and Republicans retaining control of the House of Representatives.

U.S. sales of new homes fell slightly in October, down 0.3 percent to a seasonally adjusted annual rate of 368,000. The government also said Tuesday that September sales were slower than initially reported.

In Europe, sentiment improved this week after Greece's bailout creditors agreed to pay its next installment of loans and outlined a series of measures to lower its debt load over the coming decade. Concerns remain, however, over the country's economy, which is expected to enter a sixth year of recession in 2013.

On Wall Street, the Dow Jones industrial average rose 0.8 percent to close at 12,985.11 on Wednesday. The Standard & Poor's 500 index rose 0.8 percent to close at 1,409.93. The Nasdaq composite rose 0.8 percent to 2,991.78.

Benchmark oil for January delivery was up 26 cents to $86.75 per barrel in electronic trading on the New York Mercantile Exchange. The contract fell 69 cents to close at $86.49 per barrel on the Nymex on Wednesday.

In currencies, the euro rose to $1.2950 from $1.2932 late Wednesday in New York. The dollar rose to 82.09 yen from 81.90 yen.

___

Follow Pamela Sampson on Twitter at http://twitter.com/pamelasampson

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2012-11-29-World%20Markets/id-0af162904fea464f981e2a7de82cfdf4

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Thursday, November 29, 2012

Microsoft Solves Windows Phone 8's Random Rebooting Problem

After users reported that their Windows Phone 8 handsets were randomly rebooting, Microsoft claims to have found the cause of the problem—and is planning to roll out an over-the-air update in December. More »


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/R_kbO1MtgTk/microsoft-solve-windows-phone-8s-random-rebooting-problem

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'That 70s Show' star arrested in North Carolina

STATESVILLE, N.C. (AP) ? "That '70s Show" star Lisa Robin Kelly is free on bond after being arrested for assault.

Police in the Charlotte, N.C., suburb of Mooresville arrested the 42-year-old Kelly and 61-year-old husband Robert Joseph Gilliam after responding to a disturbance at their home Monday. Both are free on bond.

Gilliam is charged with misdemeanor assault on a female. Kelly is charged with misdemeanor assault. They were taken to the Iredell County Detention Center and released on $500 bond apiece. They have a court date of Jan. 25. It's not known if either has an attorney.

Kelly portrayed Laurie Forman, sister of Topher Grace's lead character Eric, on the FOX series, which ended in 2006. She also appeared on the TV shows "Murphy Brown" and "Married . . . With Children."

Source: http://news.yahoo.com/70s-show-star-arrested-north-carolina-040626459.html

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Selecting The Best Web Hosting Service | Hugo Hosting

There are various concepts on exercise on website website content composing and its value in enhancement of the website. But my discourse is concerning the relevance of web site website content for fulfillment of a website growth business. Really how much an online improvement provider cares for your articles and other content of its private homepage?

Free of supplying relevance into the world-wide-web content composing in its possess online business there may be considerably less possibility for a website improvement organization to be victorious. Let?s use an appearance on how will ideally be the content material of the web site growth organisation.

Web material is not really the only text component of internet site. Therefore the overall images, texts, flash and alike purposes ought to be very well managed to find the particular attention with the visitors.
The material could be the major point a web site has. People come to understand what you will be and ways in which could you assist them along with your services. Your content material needs to be honestly useful.
Create your content to the point and clear. You can find no will need to just pile up the data as part of your online business. Websites are advised to inform clearly, concisely the aim of their progression.
Written content need to attract the eye on the guests and indicate itself up to date. The contents must not be created in usual bookish fashion. A communicating frame of mind and freshness of data has to be there.
The websites of a world-wide-web enhancement enterprise needs to be written concentrating on appropriate key phrases together with other Seo policies. A business might not furnish website content improvement expert services for some others, however it?s got to acquire individual subject matter developers to produce Website positioning welcoming written content.
Create articles for humans very first then for search engines like yahoo. It?s found that a web enhancement service provider is choosing net articles creating for attracting search engines like google. This pushes an internet page to lose people and engines like google as well.
Check with your prospects to enrich your articles. This process will open up scope of development. Guests will inform you what they need and what not. Should your website content can fulfill your website visitors, you get way more site visitors.

So to sum up the factors, I am able to say net growth agencies might similarly care for its possess content given it does with its customer?s web pages. Ultimately the purpose could be to reach a bit more people and acquire even more prospective buyers. Accurate utilization of word wide web content writing has ample scope for earning inbound links much too. Why treatment considerably less for web site articles for individual online site once you realize it is very important for each and every homepage? Hire the traditional process of online articles producing for achievement of your respective own blog. Push everyone with your online site and enable them truly feel your website has abundant information really worth examining and realizing who that you?re.

Main Services Offered By The Web Hosting Firms can provide you with maximum facts for Your Seek For A Web Hosting Site Ends Right Here By Douglas Fanning.Be sure to pay a visit to the written article for additional information!

Related posts:

  1. Selecting The Best Web Hosting Service Supplier
  2. Recently Introduced Web Hosting Training and Review Website Hostmonopoly.com Reveals Unknown Secrets of Selecting the Best Service Provider
  3. What To Think About When Selecting An Online Hosting Supplier
  4. Selecting A Great And Dependable Internet Hosting Firm
  5. Understanding And Selecting Business Internet Hosting Services

Source: http://www.hugohosting.com/selecting-the-best-web-hosting-service.html

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Wednesday, November 28, 2012

Excitement over holiday parade could prelude community turnaround

?

The Whitehaven Christmas Parade kicked off the holiday season on the heels of tree lighting ceremonies all over town last night.

Some say the high turnout Saturday could be a prelude to a community turnaround.

The sound of drums, horns, and cheers drew five thousand revelers to the Whitehaven Christmas Parade from all over Memphis.

"The biggest turnout ever. ?What a great sun shiny day," said Whitehaven Christmas Parade Organizer Hazel Moore. Watch video of the parade here.?

Source: http://whitehaven.wmctv.com/photo-gallery/community-spirit/88086-excitement-over-holiday-parade-could-prelude-community-turnaround

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Getting Down to Business with ?The Cloud? ? Time Warner Cable ...

When many of us hear the term Cloud Computing, we look up at the sky and think there?s this invisible bubble of data over our heads.? While it?s kind of a silly image, it isn?t entirely untrue.

Cloud Computing actually refers to using the guts on your computer (hardware and software) and data (files) virtually, online over the internet.? Businesses often use ?The Cloud? for managing their email, sharing documents remotely and even running some desktop applications. This technology allows users to share information and be productive from anywhere they can get online, without having to be on their home or office computer. Check out howstuffworks (one of my favorite websites) for a more in depth look at the technology behind Cloud Computing.

As part of its cadre of client services, Time Warner Cable Business Class (TWCBC) is a provider of Cloud Services. Through the management of their hosting partner NaviSite, TWCBC offers small-to-medium sized businesses hosted Microsoft Exchange. This gives clients the ability to have anytime, anywhere access to e-mail, documents, calendars, contacts, and SharePoint. In addition, customers of TWCBC receive additional features, such as 24X7 customer support, online data backup, and e-mail with encryption and archiving. The freedom and flexibility of Cloud Computing is especially invaluable to businesses, because it provides them with continuity and security when the unfortunate may occur, such as natural disasters, power outages or even computer viruses.

Time Warner Cable Business Class? Cloud Services are ideal for small, medium and new businesses that might not have the capital or infrastructure to invest in in-house data servers and IT professionals to manage them. TWCBC also offers these businesses the opportunity to bundle Cloud Services with their other telecommunications needs, including phone, internet, Ethernet and digital television.

YouTube Preview Image YouTube Preview Image

Click on the videos above to watch a TWCBC customer?s testimonial on how their business uses Cloud Services. You can also learn more about Cloud Services and Time Warner Cable Business Class online or inquire about its availability in your area by calling 1-866-TWC-4BIZ (1-866-892-4249).

Categories: Broadband Penetration/Deployment, Content Delivery, Cool Stuff, Future of the Industry, Northeast, What's New, Wireless

Source: http://www.twcableuntangled.com/2012/11/getting-down-to-business-with-the-cloud%E2%80%9D/

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BP suspended from U.S. govt. contracts over Gulf of Mexico oil spill

BP suspended from U.S. govt. contracts over Gulf of Mexico oil spill

November 28, 2012 - 20:49 AMT

PanARMENIAN.Net - BP has been temporarily suspended from new U.S. government contracts over the 2010 Gulf of Mexico oil spill, in a fresh blow that could have wide implications for its U.S. operations, Financial Times reported.

The U.S. Environmental Protection Agency announced on Wednesday, November 28 it had suspended the energy group ?due to BP?s lack of business integrity? as demonstrated by its conduct with regard to the Deepwater Horizon disaster.

The EPA said the suspension would temporarily prevent BP from getting ?new federal government contracts, grants or other covered transactions? until it could provide sufficient evidence that it met federal business standards. But it said the move did not affect existing agreements BP has with the government.

Under government regulations, suspensions generally may not exceed 18 months. But if there are ongoing legal proceedings at the time a suspension is issued, it can continue until those proceedings have ended. BP is facing trial on February 25 in New Orleans on civil claims arising from the disaster.

A person familiar with the matter said that to remove the bar, BP would have to show it has ?properly addressed the conditions which gave rise to the suspension?.

Source: http://www.panarmenian.net/eng/news/134762/

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Tuesday, November 27, 2012

Mexico's president-elect aims to focus on economy during U.S. visit (CNN)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories News, RSS and RSS Feed via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/266523309?client_source=feed&format=rss

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Euro zone, IMF to seek Greece deal, debt write-off main problem

BRUSSELS (Reuters) - Euro zone finance ministers and the International Monetary Fund will seek to unfreeze the second bailout package for Greece on Monday, but they first need to agree if some of the official loans to Athens might eventually be forgiven to cut Greek debt.

Euro zone ministers and their deputies have held numerous meetings and conference calls over the last two weeks to decide how Greek debt, seen at almost 190 percent of GDP next year, could be cut to a more sustainable 120 percent in 8-10 years.

Without agreement on how to reduce the debt, euro zone ministers and the IMF do not want to resume payments of loan tranches to Athens -- even though Greece has met all the conditions -- because they have no guarantee on whether the need for emergency financing will ever end.

The key question is: Can Greek debt become sustainable without the euro zone writing off some of the loans to Athens?

So far, the options for debt reduction under consideration include reducing interest on already extended bilateral loans to Greece from the current 150 basis points above financing costs.

How much lower is not yet decided -- France and Italy would like to reduce the rate to 30 basis points (bps), while Germany and some other countries insist on a 90 bps margin.

Another option, which could cut Greek debt by almost 17 percent of GDP, is to defer interest payments on loans to Greece from the EFSF, a temporary bailout fund, by 10 years.

The European Central Bank could forego profits on its Greek bond portfolio, bought at a deep discount, cutting the debt pile by a further 4.6 percent by 2020, a document prepared for the ministers' talks last week showed.

Not all euro zone central banks are prepared to forego their profits, however, the German Bundesbank among them.

Greece could also buy back its privately-held bonds on the market at a deep discount, with gains from the operation depending on the scope and price.

But the preparatory document from last week said that the 120 percent target could not be reached in 2020, only two years later, unless the ministers accept losses on their loans to Athens, provide additional financing or force private creditors into selling Greek debt at a discount.

The latest analysis for the ministers showed the debt could come down to 125 percent of GDP in 2020, one euro zone official with insight into the talks said.

FORGIVING OFFICIAL LOANS?

To cut the debt more boldly, the IMF wants the euro zone to forgive Greece some of the official loans, in what is called Official Sector Involvement (OSI) in EU jargon.

This is an idea that several countries, including Germany, the Netherlands, Finland and Slovakia, firmly reject.

On Monday, the biggest battle is likely to be over just that.

"OSI is at the core of the problems with reaching a deal," one euro zone official with insight into the talks said.

German central bank governor Jens Weidmann has suggested that Greece could "earn" a reduction in debt it owes to euro zone governments in a few years if it diligently implements all the agreed reforms. The European Commission backs that view.

German paper Welt am Sonntag said on Sunday that euro zone ministers were considering a write-down of official loans for Greece from 2015, but gave no sources and a euro zone official said such an option was never seriously discussed.

European Central Bank executive board member Joerg Asmussen told the German Bild paper on Sunday that a write-down on Greek debt should not be part of the deal, echoing repeated statements from German Finance Minister Wolfgang Schaeuble who said it would be illegal.

"It will be touch-and-go if we get a deal on Greece on Monday," a senior euro zone official said. "Euro zone countries have made concessions worth a lot of money already, so it is difficult to see how this can move even further."

French Finance Minister Pierre Moscovici said on Sunday evening that euro zone ministers made big progress to reach a common position during at a conference call on Saturday in preparation for their talks with the IMF on Monday.

"I will go with a firm determination, with a mandate from the president and prime minister, to reach a conclusion," Moscovici said. "We are very close to a solution."

Moscovici mentioned the reduction of interest on bilateral loans, foregoing ECB profits on Greek bonds and the debt buy-back as the options that would need to be applied for a deal as well as additional financing for Athens to keep it funded until 2016, rather than only until 2014.

(Additional reporting by Jean-Baptiste Vey in Paris and Erik Kirschbaum in Berlin; Editing by Alex Richardson)

Source: http://news.yahoo.com/euro-zone-imf-seek-greece-deal-debt-write-055911326--business.html

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Monday, November 26, 2012

Using Email Marketing To Your Best Advantage - Businesses

Business owners who just start out with e-mail marketing campaigns are usually unfamiliar with the proper etiquette involved. There is a certain way to handle e-mail marketing professionally that will keep your customers happy and looking forward to receiving communications from you. Below, you will find some helpful tips on marketing via email etiquette.

If you use email promoting, be sure to keep your companies branding consistent in all communications. This includes using the same fonts and colors to increase brand recognition. The emails that you send out should resemble each other enough that it is easy for customers to remember you.

Consider adding an endorsement to any followup emails you send. Put some copy in the message telling them how they can benefit immediately from your business. The ending paragraph or statement should tell the reader that they can click on the following link to submit for their order.

TIP! Include lots of useful information in all your messages. Don?t just fill them up with information about your products.

Don?t put critical information in images when sending emails. There are lots of emails that don?t show pictures automatically. Often this will result in an unsatisfactory look or unreadable message when images are prevalent. Therefore, it is important that all relevant information be given using text only; any images you wish to include should have descriptive tags.

Give your customer a clear choice to opt in to your marketing via email, and an easy way to opt out, in order to build customer confidence. Failure to do so can lead to you losing customers? trust and it will tarnish the reputation of your business. You can also get blacklisted by certain ISP?s, which can create major problems for your campaign and your business.

Now you know why email marketing protocol is so important for a business owner. Business owners that are not courteous will see subscribers drop out of email lists. If you want happy, satisfied customers who look forward to receiving emails from you, take note of the advice provided here.

TIP! You should always have permission before emailing any individual. People will not take your business seriously if you send spam.

Other articles you might like;

Source: http://elektrotehnickifakultet.com/using-email-marketing-to-your-best-advantage.html

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Blogging Technology: Keeping Your Computer Up To Date and Safe ...

We all are looking for software that will keep our computers clean and running smoothly. I recently was looking at a software website that makes your computers run like new, it is called Simplitec.com.

The software that I really like for our PC is Simplisafe; because it claims to that it will digitally delete your digital footprint. ?That means that your cookies will not be tracked back to your computer to see where you are surfing on the internet.

Other Benefits from the Simplitec software

-defragment your files
-recover data, update your files
-delete internet history and cookies to protect your privacy

For secure software, visit Simplitec?s website because they are experienced and have been in business for 18 years. That is a long time for computer companies. When it comes to software for safety and making our computers run faster it can be tough; but with much research you can find the right one that suits your needs.

While I am on the subject of software and safety, I wanted to share some great tips on safety while shopping online.

For all sorts of software information and reviews CNET?is a good resource. If I am unfamiliar with a particular software I always try to get an opinion on what experts say about it.

Recently, I was reading an article on CNET.com, How To Stay Safe When Security Shopping, and it had some really good tips such as changing your passwords and you can even have spaces between your passwords to make it more difficult for your password to be recognized. Another good tip was to make sure you logout of the internet web browser when you are done.

There are a lot of bad people that want to try to get your information so to have software that maximizes your computer experience is essential.

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Source: http://www.bubblingwitheleganceandgrace.com/?p=6741

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Law, Economics, and Superstition: Human Sacrifice

The most recent paper in my continuing project on the law
and economics of superstition: ?Human Sacrifice.?
Abstract:
This paper develops a theory of rational human sacrifice:
the purchase and ritual slaughter of innocent persons to appease divinities. I
argue that human sacrifice is a technology for protecting property rights. It
improves property protection by destroying part of sacrificing communities'
wealth, which depresses the expected payoff of plundering them. Human sacrifice
is a highly effective vehicle for destroying wealth to protect property rights
because it's an excellent public meter of wealth destruction. Human sacrifice
is spectacular, publicly communicating a sacrificer's destruction far and wide.
And immolating a live person is nearly impossible to fake, verifying the amount
of wealth a sacrificer has destroyed. To incentivize community members to contribute
wealth for destruction, human sacrifice is presented as a religious obligation.
To test my theory I investigate human sacrifice as practiced by the most
significant and well-known society of ritual immolators in the modern era: the
Konds of Orissa, India. Evidence from the Konds supports my theory's
predictions.
Enjoy.
?

Source: http://www.bullfax.com/?q=node-law-economics-and-superstition-human-sacrifice

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Sunday, November 25, 2012

Beat FMLA suit by showing you would have fired anyway ...

Employees who have taken FMLA leave and then been fired often sue. However, all is not lost for ?employers faced with such a case?if they can show they would have fired the em??ployee anyway. In fact, chances are, they?ll win.

Recent case: Ralph, a postal worker, was approved for intermittent FMLA leave. The post office had an elaborate call-in system. Employees called in and received a specific FMLA in??termittent leave authorization code if the absence was covered.

When Ralph was fired, he argued he had been terminated for taking too much intermittent leave.

But the employer showed that even if it had counted some of his covered absences against him, he still missed enough time that wasn?t covered by his FMLA certification to warrant discharge. The court tossed out his case. (Gates v. United States Postal Service, No. 10-3735, 6th Cir., 2012)

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Saturday, November 24, 2012

New molecular culprit linked to breast cancer progression

ScienceDaily (Nov. 23, 2012) ? Johns Hopkins researchers have uncovered a protein "partner" commonly used by breast cancer cells to unlock genes needed for spreading the disease around the body. A report on the discovery, published November 5 on the website of the Proceedings of the National Academy of Sciences, details how some tumors get the tools they need to metastasize.

"We've identified a protein that wasn't known before to be involved in breast cancer progression," says Gregg Semenza, M.D., Ph.D., the C. Michael Armstrong Professor of Medicine at the Johns Hopkins University School of Medicine and director of the Vascular Program at Hopkins' Institute for Cell Engineering. "The protein JMJD2C is the key that opens up a whole suite of genes needed for tumors to grow and metastasize, so it represents a potential target for cancer drug development."

Semenza and his colleagues made their finding when they traced the activity of HIF-1, a protein known to switch on hundreds of genes involved in development, red blood cell production, and metabolism in normal cells. Previous studies had shown that HIF-1 could also be hijacked to switch on genes needed to make breast tumors more malignant.

Would-be tumor cells face a host of challenges as they make the transition from working with their host to working against it, such as the need to evade the immune system and to produce more cancer cells, explains Weibo Luo, Ph.D., an instructor in the Institute for Cell Engineering and Department of Biological Chemistry who led the project. All of these efforts require switching on the right genes for the job.

To learn more about how HIF-1 works, the researchers tested a range of human proteins to see whether they would interact with HIF-1. They then sifted through the 200 resulting hits, looking for proteins involved in chemical changes to sections of DNA that determine whether or not the genes they contain are available for use. "In order for HIF-1 to switch genes on, they have to be available, but many of the genes HIF-1 activates are normally locked down in mature cells," explains Luo. "So we thought HIF-1 must have a partner that can do the unlocking."

That partner turned out to be JMJD2C, Luo says. Delving deeper, the researchers found that HIF-1 switches on the JMJD2C gene, stimulating production of the protein. HIF-1's presence also enables JMJD2C to bind to DNA at other HIF-1 target genes, then loosen those DNA sections, enabling more HIF-1 to bind to the same sites and activate the target genes.

To test the implications of their discovery, the research team injected mice with breast cancer cells in which the JMJD2C protein was not produced. Tumors with depleted JMJD2C were much less likely to grow and metastasize to the lungs, confirming the protein's role in breast cancer progression, says Luo.

"Active HIF proteins have been found in many types of tumors, so the implications of this finding go beyond breast cancer," says Luo. "JMJD2C is both an important piece of the puzzle of how tumors metastasize, and a potential target for anti-cancer therapy." Other authors of the research report are Ryan Chang, Jun Zhong, Ph.D., and Akhilesh Pandey, M.D., Ph.D., all of the Johns Hopkins University School of Medicine.

This work was supported by grants from the National Heart, Lung, and Blood Institute (contracts N01-HV28180 and HHS-N268201000032C), and by funds from the Johns Hopkins Institute for Cell Engineering.

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Story Source:

The above story is reprinted from materials provided by Johns Hopkins Medicine.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. W. Luo, R. Chang, J. Zhong, A. Pandey, G. L. Semenza. PNAS Plus: Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression. Proceedings of the National Academy of Sciences, 2012; DOI: 10.1073/pnas.1217394109

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/2nYvEp2kt_g/121124090511.htm

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The Best Small Business Marketing News & Blog Posts of the Week ...

This post is meant to be helpful for all levels of SEO expertise. You can also find DIYSEO posts classified by level of expertise on the following pages:

First, we?d like to wish a very happy Thanksgiving to all our American DIY readers. We hope you?re enjoying quality time doing all the things you enjoy and spending time with those who are special to you. Moments like these never seem to last long enough.

Let?s get started, shall we?

Beginner SEO and Marketing

Market Your Business for Free: Firesales ? If you?d like to try something a little different, or are looking for an interesting way to drive sales, why not try firesales? Never heard of them? You can read more about them on AskJinger.com

One Piece of Content, 20 Ways to Use It ? It seems like there?s never enough time in a day to create enough content. This piece from Clear Thought Consulting is an excellent way to make the most of every letter and maximize your content marketing budget.

7 Ways to Increase Engagement on Your Website ? Simply visiting your site isn?t enough. If your site traffic isn?t generating sales, it should at least be providing you with meaningful data (and moving potential buyers down the conversion funnel). To do that, each person who visits your site needs to interact with your site in a meaningful way. This week, Duct Tape Marketing shared some ways you can increase engagement levels and get more from your site visitors.

Successful LinkedIn Marketing: One Hour Per Day ? LinkedIn can be quite a daunting task to those who are new to social media marketing. It feels like it will take forever to start seeing some kind of return on your investment. Small Biz Trends did its part this week to fight this feeling and help new marketers make the most of their marketing hours.

Intermediate SEO, Marketing & Business Tips

Is Your Email Marketing Holiday Ready? ? Email marketing is a powerful weapon in your seasonal marketing, or it should be. Are you ready for the annual battle for consumer dollars?

A Strategic View of Search Engine Optimization ? Where Does SEO Fit in Your Content Strategy? ? As busy marketers and SEOs, we often become so focused on a single marketing technique that we forget to look at the bigger picture. This week, one of the brilliant posts on TopRank explained how SEO and content strategy work together to enhance and support each other.

A Content Marketing Thanksgiving Feast With All the Fixings ? While this post has some brilliant tips on content marketing, we chose this post for our round up for the fun and interesting way it presents the various concepts. In other words, it?s great information and a fantastic example of innovative content marketing. That?s like two great posts for the ?price? of one. We hope you enjoy it as much as we did. (Just don?t read it on an empty stomach.)

Awareness, Insight & Optimization: How Entrepreneurs Can Use Social Media to Launch New Products ? While this post from TopRank focuses on launching new products, keep in mind that the concepts presented here have many uses ? new marketing strategies, services, deals, promotions, etc. Have you tried this type of strategy? If so, what did you think?

Advanced SEO, Marketing & Business Links

YouTube Videos Replacing the Printed Manual ? YouTube and video definitely made great strides this year. In fact, video has almost become as vital as text for many online businesses. That doesn?t mean your videos have to actively sell or push a product. This post from V3 takes an interesting look at the video landscape.

Holiday 2012 Spending & Promotion [Infographic] ? Holiday marketing is always a bit of a guess, but this infographic has some interesting statistics that we hope will help you make more accurate decisions. ?We also found some of the stats prompted ideas for businesses and websites that may not necessarily be taking full advantage of this time of year. Either way, we found it interesting and think you will, too.

Advertise Your Local Business Using Google AdWords Express ? Google AdWords takes some time to learn and get used to, but have you tried the Express version? If not, here?s a quick guide to get you started. Just be sure to come back and let us know what you think of the platform.

Great Posts Published This Week Everyone Should Check Out

Facebook caused quite the kerfuffle this week. It seemed like everyone was talking about the recent changes the social network made that seemed to equally help and hinder small businesses. Here is just a small sampling of the posts that came out on the topic this week:

Your Facebook Page Updates Can Now Be Seen By All

New Facebook Alert Could Help Small Businesses

Get Notifications: The Free Way to Reach More Facebook Fans

Did We Really Think Social Media Would Stay Free Forever?

Google also made big headlines this week when it announced it ?Will Penalize Low-Quality Guest Blogging?. The news wasn?t all bad, however:

Google Says Submit Reconsideration Requests in Native Language

Google Now Offering High-Speed Broadband Internet

Elsewhere in the world of search engines, the Bing/Yahoo! Network announced it had Expanded to 13 New Countries.


Want to Improve Your SEO Rankings?

Source: http://blog.diyseo.com/2012/11/the-best-small-business-marketing-news-blog-posts-of-the-week-november-23-2012/

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Friday, November 23, 2012

The Daily Roundup for 11.22.2012

DNP The Daily RoundUp

You might say the day is never really done in consumer technology news. Your workday, however, hopefully draws to a close at some point. This is the Daily Roundup on Engadget, a quick peek back at the top headlines for the past 24 hours -- all handpicked by the editors here at the site. Click on through the break, and enjoy.

Continue reading The Daily Roundup for 11.22.2012

Comments

Source: http://www.engadget.com/2012/11/22/the-daily-roundup-for-11-22-2012/

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Fire Destroy's Family's Home Near Desoto - St. Louis News ...

Posted on: 8:34 pm, November 22, 2012, by George Sells, updated on: 10:54pm, November 22, 2012

JEFFERSON COUNTY, MO. (KTVI) ? A family?s home is destroyed on Thanksgiving, while the family was away from their home near Desoto, Missouri.? The fire broke out around 1:50 pm on Klondike Road, off Highway E, just south of Desoto.

The Desoto Fire District responded to the fire, calling in a two alarm fire once they arrived on scene.? The volunteer firemen had to battle wind and the lack of water to put out the blaze, using a near-by lake to get water.

The home was a total loss and a neighboring home suffered damage to its roof and siding.

Three firefighters were slightly injured and treated on scene.

Fire officials are looking at an electric turkey smoker as a possible cause of the fire.

Source: http://fox2now.com/2012/11/22/fire-destroys-familys-home-near-desoto/

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Thursday, November 22, 2012

best small dog breeds in the world - a2z Pets Info

Your decision of getting a pet dog to your home will be welcomed greatly by your family members. However your selection from the best?small dog breeds in the world is of great concern till you work on it. The thing is fine if you had a pet earlier. If you are acquiring a pet for the first time it is your responsibility to search for the right breed. With the advent of internet the task of searching the small dogs is made and easy and fast. Look for the tiniest size dog which is generally preferred by the beginners.

Obviously you will pick them as they look cuter. As the small dogs live longer some prefer these breeds to have the companionship for long years. Such small breeds live up to 16 years. For the best?small dog breeds in the world, you can even get nice books from the city libraries or even buy one if you can.

Prerequisites before selection

Before attempting your selection know about the prerequisites of becoming a owner of a pet dog. Prepare your home to accommodate your pet and check with your family members for their acceptance. This is very important aspect of getting a pet dog of any breed or even size. Involve them in the selection process and have their opinion from your Google search about the best?small dog breeds in the world. At times they even suggest the best breed as seen in their friends place. Call friends who own dogs to find out the cost involving for maintaining a dog. This will help you to plan your budget. Select the appropriate place in your home for the arrival of a new family member.

small dog breeds

Select the most popular breed

Choosing the right breed of small dogs concerns many factors like country, cost and availability. There is no special season in getting a new dog. Most dog owners do it by instinct without planning. A true dog lover does not wait a right time but he or she will not miss the right opportunity. Look for the post popular dog breed and smallest Chihuahua which is considered to be the most fun loving in America. This variety has a life expectancy of around 12 to 18 years.

Generally a grown up will weight over six pounds and can grow up to six to nine inches height. The next familiar one is the great and well known Pomeranian, which is the best entertaining dog in all parts of the world. The name of this variety varies in different countries. An adult type will grow up to one foot and weighs around seven pounds. The Toy Fox Terrier is the smallest dog in America, which is used generally for hunting purpose. Do not miss to look for other types such as Yorkshire Terrier, Toy Poodle etc. The choice is limitless and finally you have to make your own judgment in getting the best?small dog breeds in the world for your loved family members.

Search for details by online

For a wide range of selection browse internet. Make a Google search for the best?small dog breeds in the world and select the final one that suits to your interest and budget. Apart from searching in the online shopping, you can also visit some of the dog shows in your city to have an opinion about the small breed dogs. Certainly you are sure to have the best practical insight about these cute breeds.


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Source: http://www.a2zpetsinfo.com/dog/dog-breeds/best-small-dog-breeds-in-the-world.html

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UzA: Family and Childhood are under Reliable Protection






Family and Childhood are under Reliable?Protection

UzA, Nazokat Usmonova, Sarvar Urmonov, 21 November 2012, 15:17

An international forum on the theme of "Spiritual and moral foundations of society in the social support system of childhood and family" started in Tashkent.

The forum is being organized by the Republican Centre for Social Adaptation of Children, Sen yolgiz emassan (You are not alone) Republican Public Children's Fund together with the Ministries of Education, Higher and Secondary Special Education, Health, Labor and Social Protection, Culture and Sports, Tashkent city hokimiyat, representative offices of UNICEF and UNESCO in our country.

Senators, deputies, heads of various ministries and departments, public organizations, teachers, lawyers, doctors, members of the media and foreign experts participate in it.

Permanent representative of the Republic of Uzbekistan to UNESCO, Chairman of the Board of Trustees of the Republican Centre for Social Adaptation of Children and the Children?s Fund Sen yolgiz emassan Lola Karimova-Tillayeva, chairman of the Federation of Trade Unions T.Norboyeva, Deputy Prosecutor General A.Sharafiddinov, Minister of Public Education T.Shirinov, Minister of Higher and Secondary Special Education B.Hodiyev, A.Alimov Health Minister and Minister of Labor and Social Protection A.Haitov and others spoke about the reforms carried out in Uzbekistan in this sphere. They noted that in the years of independence, such noble traditions like care about children and respect for mothers are being enriched with new content.

In our country, implementation of the principle of "Healthy mother ? healthy child", upbringing of harmoniously developed generation has become a truly national movement. All the necessary conditions have been created to ensure a healthy and worthy life of our people, maternal and child health, education, spiritual and physical health of young generation and to promote sports.

The head of UNICEF office in Uzbekistan Jean-Michel Delmont, Deputy Permanent Representative of the United Nations Development Programme in Uzbekistan Jako Silliers, head of the UNESCO office in Uzbekistan Krista Pikkat as well as Extraordinary and Plenipotentiary Ambassador of Israel to Uzbekistan Hillel Newman noted at the forum that the Uzbek national model of well-being of families, social protection of maternity and childhood receives special recognition also on an international scale.

In the implementation of the State program "Year of Family", the scope of the reforms has expanded and the effectiveness has been increased even more. The activities aimed at further strengthening the spiritual foundations of our society, maternal and child health, improving the living conditions of families and education of harmoniously developed generation are being carried out consistently.

Progressive steps towards full coverage of pregnant women screening examination, vaccination of children against infectious diseases, increasing the medical culture of young people allow to prevent the birth of children with disabilities, as well as to reduce the rates of congenital and hereditary diseases.

The cooperation of "Family - mahalla - educational institution" plays an important role in creating a high spiritual atmosphere in a society and in the fight against the negative influences to our national mentality.

The Universities of parents were organized in all mahallas by Charity Foundation Mahalla, the Women's Committee, the Ministry of Public Education and together with other organizations. These social structures are important in explaining to parents, the legal, psychological and social aspects of upbringing of children and providing them with necessary advices, in detail.

In our country, in the process of practical measures for a strong and targeted social protection of all children, regardless of their nationality and social status, a special attention is given to the further improvement of the activities of orphanages, full education and vocational training of their students.

The issues of health promotion of children from needy families and children with difficult life, protection of their rights and interests, enhance social protection and to facilitate their integration into society are considered as the priority tasks of the Republican Children's Fund Sen yolgiz emassan and the Republican Centre for Social Adaptation of Children.

The issues of social protection of motherhood and childhood as a basis for ensuring the future of children and youth, family well-being, legal, psychological, educational, medical and rehabilitative aspects of protecting young people, families and maternity, ways to improve the social integration of children with special needs on the basis of national values, spiritual foundations of family protection were discussed in detail at the sectional meetings of the forum.

Deputy Prime Minister of the Republic of Uzbekistan A.Ikromov made a speech at the opening ceremony.

Latest news:

Family and Childhood are under Reliable?Protection

Uzbekistan ? Our Common?House

The Guarantor of Our?Rights

Ruslan Becomes Champion of Central?Asia

National Flag is a Symbol of the State?Sovereignty

Source: http://uza.uz/en/society/3117/

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Reference and Education Posting Category

This can be a perspective comparable to creativity expert Ken Robinson's analysis about how precisely people lose power they have to ponder the possible uses of a paper clip since they grow older, simply because they stop communicating with them about the nature of the paper clip. Comforting news for such people is that government is providing a lot of grants and support if you're going through their studies. Presently the education sector with the nation has good openings for numerous educated youth in the country. All the students are strictly necessary to follow the proper time table of the school to keep up the regularity and worthiness within their work. You are certainly not required to appear for any written entrance exam for admission into most with the B. masterdegrees-online.com And today, the greatest question personally is, how is it that anyone get going to a school to gain elementary education, when that education is performing no good to him inside future.

A career in the relevant field of studies may be the first choice. Find employment in the kind of type of cooking that interests you. With the standard of education getting higher, an organization's demand with an individual's a higher level education can be getting higher. It therefore needs to be taken being a subject taught in schools to further improve knowledge around the subject matter; something merely as human anatomy or biology class. - make a detailed list in the pros along with the cons and consider your future carefully. The biggest educational centre in the country is Delhi. schools listing

The educators are expected to teach subjects like English, mathematics, basic science, history, geography along with a different language. India should think carefully just how much foreign system of education has helped her. (3) Politicizing education: Merit isn't any longer regarded as it really is now " individual preference know" and never "what it is possible to deliver" Technocrats (educationists usually are not appointed Commissioner of education and education board). The exam is conducted to recruit the educated youth with the nation inside post of teachers as well as non teaching positions in several government affiliated schools all across the nation. These teachers aren't only expert within their teaching concepts and also they know the deep child psychology. The reasons for every state is the education of the company's youth.

What will be the gaps in education that you simply want assembling your shed to resolve using the help of a funding assistance. The team of professionals at Distance learning India has vast experience within the field of providing Distance Education using the easiest mode of learning. This also designed a bond among people of India which can be keeping this country together. It is one from the best and widely preferred education companies that are considered as a global leader in the field of training and development. The locals here are provided with the most effective possible public amenities and privileges. Teflon shaft seal, ceramic shaft seal and lubricated shaft seals (Buna, Teflon, Viton) are standard.

This means enrollment in an accredited college, university, vocational school, and other accredited postsecondary educational institution. This system Improves communication at all levels inside the institution in order to align the organization with the higher standards institutional goals. Once they are shown a true picture of sex and its particular consequences their mental status relaxes and they are easily able to cope with other social taboos. In addition, if it condition is not met inside a period of eight years after graduation, a student will be required to pay back the grant cash with interest. Money thus availed from grants might be used for paying tuition fees, buying books, buying study materials, arranging housing facilities etc. All the various components and sections in the question paper must be studied with equal emphasis. Thousands of individuals are signing up a year to take classes online since they allow these to continue with their life and receive education at the identical time.

Source: https://wiki.waratah.spcc.nsw.edu.au/groups/2012bathursttripmccowenb/weblog/b087a/

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Wednesday, November 21, 2012

Tensions loom as Obama meets Japan, China leaders

PHNOM PENH (Reuters) - In his first meeting with a Chinese leader since his re-election, U.S. President Barack Obama said on Tuesday Washington and its chief economic rival must work together to "establish clear rules of the road" for trade and investment.

His comments on the final leg of a three-day Southeast Asian trip follow a U.S. election campaign in which China was repeatedly accused of unfair trade practices and illustrate the work ahead in a region already simmering with tension over territorial disputes involving Beijing.

"It is very important that as two of the largest economies in the world that we work to establish clear rules of the road internationally for trade and investment," Obama told Chinese Premier Wen Jiabao before an East Asia Summit of Asia-Pacific leaders in the Cambodian capital Phnom Penh.

Divisions over Chinese sovereignty claims in the South China Sea marred a Southeast Asian leaders' summit on Monday and roiled a July meeting of the Association of Southeast Asian Nations (ASEAN) where foreign ministers failed to agree on a communiqu? for the first time ever.

"I'm committed to working with China and I'm committed to working with Asia," Obama said. China and the United States had a "special responsibility" to lead the way on sustained global growth, he added before the meeting was closed to media.

Wen highlighted "the differences and disagreements between us" but said these could be resolved through trade and investment.

Japanese Prime Minister Yoshihiko Noda told Obama earlier that mounting Asian security problems raise the importance of the U.S.-Japan alliance, a veiled reference to tensions over Chinese sovereignty claims and maritime disputes.

"With the increasing severity of the security environment in East Asia, the importance of the Japan-U.S. alliance is increasing," Noda told Obama in a bilateral meeting in Phnom Penh.

Obama is expected to raise Asia's divisive territorial disputes in closed-door meetings later on Tuesday at the East Asia Summit, which also includes leaders from ASEAN, India, South Korea, Australia and New Zealand.

ASEAN includes Brunei, Cambodia, Indonesia, Laos, Malaysia, Myanmar, the Philippines, Singapore, Thailand and Vietnam.

ASEAN Secretary-General Surin Pitsuwan insisted Southeast Asia remained united, even as U.S. ally the Philippines objected to Cambodia's statement on Monday that ASEAN agreed not to "internationalize" the maritime dispute ? diplomatic code for saying it would resolve the issue without U.S. involvement.

"We're not going to allow the issue to cloud or to affect other pursuits that we're doing together here," Surin told reporters.

China's claims of sovereignty over the South China Sea set it directly against Vietnam and the Philippines in one of Asia's most divisive and vexing security problems. Brunei, Taiwan and Malaysia also lay claim to parts of the sea.

Sino-Japanese relations are also under strain after the Japanese government bought disputed islands known as Senkaku in Japan and Diaoyu in China from a private Japanese owner in September, triggering violent protests and calls for boycotts of Japanese products across China.

China says both disputes involve sea-lanes vital for its economy.

"It's going to be very important for us to coordinate effectively to promote jobs and growth, trade and investment throughout the Asia Pacific region," Obama told Noda.

"HOW CAN THERE BE A CONSENSUS?"

China prefers to address conflicts through one-on-one talks.

On Monday, Noda challenged efforts by summit host Cambodia, a staunch China ally, to limit discussions on the mineral-rich sea.

Cambodia had said Southeast Asian leaders had agreed not to internationalize the South China Sea row -- a claim that was strongly disputed by Philippine President Benigno Aquino who raised the possibility of finding an "alternative route" to discuss the issue with countries outside the 10-member ASEAN.

Alternative diplomatic routes for the Philippines would likely involve the United States, one of its closest allies, which has said it has a national interest in freedom of navigation through the South China Sea's vital shipping lanes.

"How can there be a consensus? A consensus means 100 percent," said Philippine Foreign Minister Albert del Rosario. "It was translated into a consensus without our consent."

ASEAN on Sunday agreed to formally ask China to start talks on a Code of Conduct (CoC) aimed at easing the risk of naval flashpoints, according to Surin. But Wen played down the need for urgent action in talks on Sunday night with Cambodian Prime Minister Hun Sen.

Late on Monday, Obama and Southeast Asian leaders launched a trade initiative known as the U.S.-ASEAN Expanded Economic Engagement, which is aimed at smoothing a path for Asian nations to link up with the Trans-Pacific Partnership, a pact the United States is negotiating with 10 Asian countries and the Western Hemisphere, the White House said.

The Trans-Pacific Partnership excludes Chinese participation until it undertakes significant economic reforms.

(Additional reporting by Mark Felsenthal, Stuart Grudgings, Prak Chan Thul and James Pomfret, and Jutarat Skulpichetrat; Writing by Jason Szep; Editing by Raju Gopalakrishnan)

Source: http://news.yahoo.com/asia-tensions-loom-obama-meets-japan-china-leaders-054612574.html

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Engadget's Black Friday 2012 roundup

Engadget's Black Friday 2012 roundup

They're playing Christmas music on all the radio stations and government buildings have begun decking the halls with non-denominational decorations. All of this can only mean one thing: it's time for the mad holiday rush. Once you've polished off that turkey dinner and put on a pair of your least flattering sweatpants, be sure join us after the break for some of the merriest deals on consumer electronics that the internet -- and your local big box shop -- has to offer. Yes, ladies and gentleman, it's Black Friday time.

Continue reading Engadget's Black Friday 2012 roundup

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/uNXzhM1d-wc/

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Hungry for Thanksgiving TV? Here's What's Being Served!

By the time Thanksgiving rolls around on Thursday, most of your favorite TV characters will have already celebrated it. On Tuesday, characters on Fox's New Girl and The Mindy Project, NBC's Go On, and ABC's Don't Trust the B*** in Apt. 23 all talked turkey with holiday-themed episodes. NBC's Guys With Kids and Chicago Fire are airing Turkey Day-styled episodes on Wednesday, at 8:30 p.m. ET and 10 p.m. ET, respectively. But what's on TV on the Big Day itself? Holiday specials and lots and lots of rerun marathons. Here's a sampling. 

Source: http://www.ivillage.com/thanksgiving-2012-tv-shows-and-specials/1-a-503559?dst=iv%3AiVillage%3Athanksgiving-2012-tv-shows-and-specials-503559

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