Thursday, January 3, 2013

Key mechanism in calcium regulation discovered: May help lead to new drugs for neurodegenerative diseases

Jan. 3, 2013 ? All living cells keep their cellular calcium concentration at a very low level. Since a small increase in calcium can affect many critical cellular functions (an elevated calcium concentration over an extended period can induce cell death), powerful cellular mechanisms ensure that calcium concentration quickly returns to its low level.

?It is known that impairments of cellular calcium regulation underlie almost all neurodegenerative diseases. For example, age-related loss of calcium regulation was shown to promote cell vulnerability in Alzheimer?s disease.

In a study recently published in the Journal of Neuroscience, Hebrew University of Jerusalem researchers, along with others from Israel and the US, presented their findings of a previously undescribed cellular mechanism which is essential for keeping cellular calcium concentration low. This mechanism operates together with other already characterized mechanisms.?

Dr. Shirley Weiss and Prof. Baruch Minke of the Hebrew University?s Institute of Medical Research Israel-Canada (IMRIC) and the Edmond and Lily Safra Center for Brain Sciences (ELSC) characterized this mechanism using photoreceptor cells of the fruit fly, which is a powerful model for studying basic biological processes.

They found that a protein-designated calphotin (a calcium buffer)?operates by sequestering elevated calcium concentration. Genetic elimination of calphotin led to a light-induced rise in cellular calcium for an abnormally extended time, leading to retinal photoreceptor degeneration in the fruit flies.

The researchers stress that this kind of research, leading to a better understanding of the fundamental mechanisms underlying cellular calcium regulation, is critical for the development of new drugs and treatments for neurodegenerative diseases.

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The above story is reprinted from materials provided by Hebrew University of Jerusalem, via AlphaGalileo.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. S. Weiss, E. Kohn, D. Dadon, B. Katz, M. Peters, M. Lebendiker, M. Kosloff, N. J. Colley, B. Minke. Compartmentalization and Ca2 Buffering Are Essential for Prevention of Light-Induced Retinal Degeneration. Journal of Neuroscience, 2012; 32 (42): 14696 DOI: 10.1523/JNEUROSCI.2456-12.2012

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/bPcyq2WU5rQ/130103073240.htm

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Wednesday, January 2, 2013

Social Media Marketing and the Law: What You Need to Know

Social media marketing can be a tricky business. Brands are constantly trying to find new ways to make their social strategy stand out, but when doing so there is a legal side to take in to account as well. And when it comes to that legal side, it?s not always clear what is required.

That?s why TNW Academy introduces, especially for all of our UK readers: The Legal Side of Social Media. In this live interactive class you will learn:

  • the legal side of user generated content
  • how to ensure your brand ambassador initiatives are up to par
  • best practices for blogger outreach programs
  • legal watch outs for activating competitions on social media

The Legal Side of Social Media is in collaboration with Jo Farmer,?partner at London?s law firm Lewis Silkin. For over 15 years Jo has been advising agencies and brands on their day to day commercial risk management.?In 1,5 hours Jo will give a refreshing talk about the legal aspects of a social media promotion, share examples with you of how things have gone wrong and how they could have been avoided. As a UK lawyer, Jo?s focus will be on English law.

Join this class and tap in to the legal experience of Jo?and ask all your legal questions about your next brilliant social media campaign.

For who??All social media managers & marketers in the UK
Level: Beginner & intermediate enthusiasts
Duration: 1,5 hours with enough room to ask your questions
Day & time: January 15 ? 3pm London time
Where: online (webinar)

Source: http://thenextweb.com/voice/2013/01/02/social-media-marketing-and-the-law-tnw-academy/

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Supervisor Leadership Program - Sales Management Training ...

Job Duties & Responsibilities This career track is well suited for finance, accounting, economics, marketing, risk management, management, and general business majors. To be eligible for the Supervisor Leadership Program you must have a minimum overall GPA of 3.20 in your undergraduate studies. A college degree is required for this program.

GEICO offers you the chance to launch your career in our selective Supervisor Leadership Program. In this program, you'll gain a comprehensive understanding of one of our major insurance operations: Sales, Customer Service, Claims or Auto Damage. (Selection into a particular track is determined by your interests and the business needs of the location.)

Length of the program varies by track; the Sales and Service tracks are approximately 15 - 18 months, while the Claims and Auto Damage tracks are approximately 2 - 2.5 years due to additional classes and rotations needed to become fully trained. Each track provides you with an excellent opportunity to learn about the dynamic insurance industry and accelerate to a supervisor position.

GEICO believes that in order for you to be an effective team supervisor within our call center environment, you must first understand the intricacies of our insurance business and the job function you'll one day manage. Therefore, after completing our extensive classroom training and passing any necessary insurance exams, you'll have the good fortune to experience the sales, customer service, claims or auto damage adjuster position firsthand.

During this time, you'll receive mentoring from a senior-level manager and work on projects that are critical to the department's success. As you progress through your training, you will serve as a mentor, and assist in the training and coaching of new associates. Toward the latter part of your program, you will attend on-site supervisory preparation classes.

Our ultimate goal is to have you ready to supervise and motivate a team of your own!

We are committed to giving you the tools, knowledge and support that you'll need to advance your career at GEICO. Associates who started in our Supervisor Leadership Program have been promoted to supervisor, trainer and even business unit managers.

Candidate Qualifications GEICO seeks bright, motivated graduates to join our fast-track Supervisor Leadership Program - Sales track. In this entry level management training program, you'll spend 12 to 18 months learning about our sales operations from the ground up. Careers at GEICO offer industry-leading training, professional licensing, career advancement, and a competitive Total Rewards benefits package!

Our Supervisor Leadership Program (SLP) provides an excellent opportunity to experience our dynamic industry and accelerate to a Sales Supervisor position. In order to one day lead a Sales team, you will first:

* Attend on-site training, pass necessary insurance exams, and get your professional license
* Drive our company growth by selling our exceptional products and gain hands-on experience
* Receive mentoring from management
* Work to meet goals, achieve top results, and demonstrate your leadership potential
* Work on projects that are critical to the Sales department's success
* Coach associates, and assist in their training and development
* Attend supervisory preparation classes toward the end of your program

Our goal is to prepare you to effectively supervise a Sales team! SLP participants advance through the program based upon performance. Associates who started in this program have been promoted to supervisors, trainers and managers.

Candidate Qualifications:

* Bachelor's degree in business, or a degree and at least four completed core business courses (Accounting I & II, Finance, Statistics, Marketing, Business Law, Macro/Micro Economics or Information Systems)
* At least a 3.2 cumulative undergraduate GPA
* Demonstrated leadership experience on campus, within the community and/or at work
* Very good computer, analytical and problem-solving skills
* Effective written and verbal communication
* Strong time management and multi-tasking abilities
* High level of dependability
* Willingness to start at the entry level and learn our business from the ground-up
* Desire and ability to one day lead a team
* U.S. work authorization required. Sponsorship is not available for this program.

Important Position Details The GEICO Supervisor Leadership Program requires a Bachelor's degree in a business-related field. Candidates with a non-business degree who have taken at least four core business courses (finance, accounting I and II, macro / micro economics, marketing, business law, statistics and/or information systems) will also be considered.

This entry level program requires applicants to have at least a 3.2 cumulative GPA in your undergraduate studies, as well as demonstrated leadership experience on campus, within the community and/or at work. Applicants who do not meet these minimum requirements are encouraged to consider other career opportunities at GEICO.

How To Apply Please click Apply Now to complete your application; you will need an active email address and phone number. Additionally, we request that you enter any work experience that you've had within at least the past five years. Once you begin your application you can save it if you need to access it later. About GEICO Driving your career. Insuring your future.

For more than 75 years, GEICO has stood out from the rest of the insurance industry! We are one of the nation's largest and fastest-growing auto insurers thanks to our low rates, outstanding service and clever marketing. We're an industry leader employing thousands of dedicated and hard-working associates. As a wholly owned subsidiary of Berkshire Hathaway, we offer associates training and career advancement in a financially stable and rewarding workplace.

Our associates' quality of life is important to us. Full-time GEICO associates are offered a comprehensive Total Rewards Program*, including:

* 401(k) and profit-sharing plans
* Medical, dental, vision and life insurance
* Paid vacation, holidays and leave programs
* Tuition reimbursement
* Associate assistance program
* Flexible spending accounts
* Business casual dress
* Volunteer opportunities

GEICO is an equal opportunity employer. Background checks, credit checks, drug testing, and health assessments are required as part of our pre-employment process.


Requisition #: 2778

Source: http://jobs.insurancesalesweb.com/c/job.cfm?site_id=1636&jb=11831588

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0 - Philadelphia Weekly

Blue flashes. That?s one thing I won?t forget. Blue flashes, and fighting an early morning fire, and the slow, wailing death of cars.?

When Sandy rolled in, at first our focus was on the water. From our bedroom window, we anxiously watched our little offshoot of Barnegat Bay rise, rise, rise, and we wondered if it would drown out the life we knew. The idea that the morning of Oct. 30 would not be a normal one was clear in the overnight skies: All night, as we saw the flood bury our street and climb the steps of our front porch to within inches of the house itself, transformers were popping in brilliant blue flashes. The sky would alight with them, wooosh, then gone, blue sheet lightning rising from the ground. They came from every direction? wooosh, wooosh, all night, until eventually they seemed a sort of heartbeat. If you imagined hard enough, you could envision them as the flashes of alien weaponry bombarding the neighborhood.?

While this happened, cars died.?

Turns out a submerged car goes through observable death throes; it dies in painful stages like a wounded wild animal. As the water rises over the dashboard, first the interior lights come on. Then the headlights. If the trunk is electronic, it pops open. Then any electronic horns or security alerts start to wail, slow and wet and mournful. That?s what happened as the floodwaters came in: First our family?s car died, the sudden glow of the inside lights signaling the beginning of the end. Then the one next to it, headlights erupting in a spasm of death as the water rose from tires to hubs to fenders to hood to dash to death. One after another, all the cars on our block did this. We timed the flood by them: headlights, horns, and that?s another neighbor with no means of transportation. My wife?s car cried for an hour before it died, and up the street, an alarm blared on and off in five-minute spurts for two hours: BEEEEP. BEEEP. BEEEP.?

There was no sleeping.?

In the morning, a horn started to wail next door. I looked out the window. The new neighbors? SUV was dying. They had just moved in; we didn?t really know them. At first, Natalie and I joked about why theirs had taken so long when all the other cars on the block had succumbed overnight. ?

Then smoke started to pour from it. The electronics, just now frying in the water, had caught on fire. The vehicle was parked next to their garage?and underneath trees that touched our house. If it became fully engulfed in flames, both our homes would be in grave danger.?

I jumped out into oil-covered water and tried to find our garden hose in the debris and muck. Where was it? The water level was over my hips, even well after the peak of the storm, and it was murky. I couldn?t see anything through it.?

The neighbor, Jeff, came out with a pot and started struggling with the fire. He splurged pots of floodwater onto it, but now the entire dash of the truck was in flames. ?

My hands felt urgently through the muck. Finally I bumped into the hose, got it going and trudged over as fast as I could, spraying down the flaming vehicle. He smashed the windshield so we could get more water onto the flame-doused dash. We finally put it out.?

Breathing heavily, soaked and cold and smelling like fuel oil, it struck me just then that the morning was beautiful. The sky was clear and blue?or seemed so after yesterday?s tempest. The world around me was surreal, eerily changed from the familiar landscape I knew, but it was a beautiful morning all the same. Jeff and I caught our breath and shook our heads at the absurdity of it all.?

This is how I got to know my new neighbors.?

* * *

Jeff and Kathy Nolan had moved in just weeks before Sandy struck. The house had been on the market for a while, the previous owner a weekend owner frustrated he couldn?t get the nice payout he hoped for. When the Nolans moved in, Natalie and I were glad they didn?t seem like 20-somethings eager to party every summer weekend?we already have plenty of Jersey Shore types in our neighborhood, thanks. The few cross-driveway conversations we had were pleasant. Seemed like good people.?

And then, there we were, putting out a fire raging in his car.?

What followed was a week of tremendous hospitality?of getting to know our neighbors and, more importantly, getting to know how amazingly generous they were. Jeff and Kathy had a gas oven. We did not. Their water was heated by gas. Ours was not. So the first night after the storm, they invited us over to take a shower and share the food we all had, lest it spoil. We bathed, felt human, and broke bread together, commiserating in the unreality around us.?

We did that every night for a week. At 8 a.m., Kathy would knock on our door with a kettle of scalding hot water so we could make tea. That warm liquid was the morning boost I needed to get up and tackle the cleanup work that so desperately needed doing. All week long, we met at the Nolans? and had dinner by candlelight, pooling the food from three households, enjoying what seemed like feasts at the time, wondering if maybe this was how people lived 200 years ago. We talked about ourselves, our families, our outlooks. It was nice. ?

It?s amazing how you get to know one another when the world seems to have fallen apart.?

The same, I found out later, was happening elsewhere. When I spoke to Joanne LaCicero of the neighboring island town of Lavallette, just across the bay, her story made mine seem quaint. My family and I were sharing our tiny two-bedroom space with my mother-in-law?whose house was destroyed by the storm?and coming together with the couple next door for only a few hours each evening. Joanne and her family, on the other hand, were sheltering more than a dozen neighbors in their home.?

*/ var formWrap = $( 'add_comment_form' ); var formDivs = $$( '#add_comment_form div' ); for ( i = 0; i ' + name + ' said... on ' + timeStamp }); var commentPar = new Element( 'p', { 'html': '?' + comment + '?' }); var ruleDiv = new Element( 'div', { 'class': 'rule' }); authorPar.inject( commentDiv ); commentPar.inject( commentDiv ); commentDiv.inject( commentWrap ); ruleDiv.inject( commentWrap ); } else { msgPar.innerHTML = "Comment has been sent for approval"; } } } // FUNCTION TO DISPLAY LATEST COMMENT ON MULTIMEDIA PAGES TRIGGERED BY AJAX CALL BACK function showMMComment(theName, theComment) { // 'name' and 'comment' have placeholder content for testing, actual data would be sent from DB var name = theName; var comment = theComment; var flagged = false; var status; var error; /* COMMENT HTML MARKUP STRUCTURE

*/ var formWrap = $( 'media_add_comment' ); var commentForm = formWrap.getElement( 'form' ); commentForm.setStyle( 'display', 'none' ); var msgPar = new Element( 'p', { 'html': 'Thank you, your comment has been added.' }); msgPar.inject( formWrap ); if ( comment != '' ) { if ( !flagged ) { if ( name == '' ) name = 'Anonymous'; var commentWrap = $( 'comments_wrap' ); var commentUl = commentWrap.getElement( 'ul' ); var commentLi = new Element( 'li', { 'class': 'clear' }); var numDiv = new Element( 'div', { 'class': 'num', 'html': '?' }); var commentPar = new Element( 'p', { 'html': '

' + comment }); numDiv.inject( commentLi ); commentPar.inject( commentLi ); commentLi.inject( commentUl ); } else { msgPar.set( 'html', 'Comment has been sent for approval' ); } } } function displayNewComment() { var msgP = document.getElementById("msg"); msgP.innerHTML = "Thank you for your submission. Your comment has been added below."; if(comment != "") { if(!flagged) { var commentSection = document.getElementById("ajaxSection"); var commentDiv = document.createElement("div"); var timeStamp = 'Jan 2, 2013 at 02:05PM'; commentDiv.innerHTML = '

'; commentSection.appendChild(commentDiv); } } } function validateCommentForm(form){ var fieldEmail = document.getElementById("field.email"); var fieldName = document.getElementById("field.name"); var nameValue = fieldName.value; var emailValue = fieldEmail.value; var filter = /^([a-zA-Z0-9_\.\-])+\@(([a-zA-Z0-9\-])+\.)+([a-zA-Z0-9]{2,4})+$/; if (filter.test(emailValue)) { var fieldBody = document.getElementById("field.body") var bodyValue = fieldBody.value; bodyValue = bodyValue.replace(/&/g,"&"); bodyValue = bodyValue.replace(/,"/g,">"); bodyValue = bodyValue.replace(/\r\n/g,"

"); fieldBody.value = bodyValue; if(navigator.appName == 'Microsoft Internet Explorer') { if(document.getElementById('submit').disabled) { document.getElementById('submit').disabled=false; } else { document.getElementById('submit').disabled=true; } } return insertComment(form,true,function(){return showEditorialComment(nameValue, bodyValue)}); } else { alert('Please enter a valid Email below.'); form.elements[field.email].focus(); return false; } }

Source: http://www.philadelphiaweekly.com/news-and-opinion/185320151.html

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Video: The road ahead after 2012's political circus

Hugh Hefner, 86, weds Crystal Harris, 26

??Hugh Hefner and Crystal Harris are on their way to happily ever after! The Playboy founder, 86, and his model girlfriend, 26, tied the knot in an intimate ceremony on New Year's Eve at the Playboy Mansion in Los Angeles, a mansion source tells Us Weekly.

Source: http://video.msnbc.msn.com/hardball/50240237/

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Tuesday, January 1, 2013

Using the Internet to Find Affordable Auto Insurance | Celeste Bright

With our society becoming increasingly reliant on cars every day, it is essential to purchase an effective car insurance plan. Auto insurance includes many benefits. Auto insurance will protect your against financial loss, cover damage to or theft of your car, pay for your legal responsibility if you are responsible in an accident. Auto insurance rates and coverage can vary greatly depending on the company, which can be frustrating. Instead of spending hours researching on your own, why not let us do the work for you and provide you with all your options? Our site is your resource to find an assortment of quotes on car insurance, home insurance, renters insurance, and health insurance. Buying insurance doesn?t have to be a stressful experience; by using our website, it never will be. Free Insurance Quotes Buffalo NY

Source: http://celestebright.com/using-the-internet-to-find-affordable-auto-insurance-2/

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Video: Sen. Corker: 'Highly Likely' Vote on 'Fiscal Cliff' Bill ...

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Source: http://video.msnbc.msn.com/cnbc/50335068/

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